| Raising Cane's Chicken Fingers | Baton Rouge | 1996 |
| Ralph Lauren (marca) | Nova Iorque | 1967 |
| Ramada | Phoenix | 1953 |
| Rand McNally | Chicago, Skokie | 1856 |
| Rawlings | Town and Country | 1887 |
| Rayovac | Middleton | 1906 |
| Razer | George Town, Singapura, Carlsbad, Irvine, São Francisco | 1998 |
| RC4WD | São Francisco | 2001 |
| Realty Income | San Diego | 1969 |
| Red Ventures | Charlotte, Fort Mill, Indian Land | 2000 |
| Reebok | Boston | 1895 |
| Regent Seven Seas Cruises | Miami | 1990 |
| Regions Financial Corporation | Birmingham | 13 de julho de 1971 |
| Remington Arms | Madison | 1816 |
| Remington Rand | Buffalo, Nova Iorque | 1927 |
| Renaissance Technologies | Setauket-East Setauket | 1982 |
| Replit | São Francisco | — |
| Republic Airways Holdings | Indianápolis | 1973 |
| Ring Ka King | Pune | 2011 |
| Rite Aid | Filadélfia, East Pennsboro Township | 1962 |
| RKO Pictures | Manhattan | 23 de outubro de 1928 |
| Roku | Los Gatos | outubro 2002 |
| Room to Read | São Francisco | 2000 |
| Rough Draft Studios | Glendale | 1990 |
| Roxio | Santa Clara | 2001 |
| RR Donnelley | Chicago | 1864 |
| Ryan Aeronautical Company | San Diego | 1934 |
| S. C. Johnson & Son | Racine | 1886 |
| SAE International | Warrendale | 1905 |
| Salesforce | Salesforce Tower, São Francisco | 3 de fevereiro de 1999 |
| San Diego Football Club | San Diego | 18 de maio de 2023 |
| San Diego Studios | San Diego | 2001 |
| Santa Cruz Operation | Santa Cruz | 1979 |
| Sara Lee Corporation | Downers Grove | 1939 |
| Schecter Guitar Research | Los Angeles | 1976 |
| Sealy Corporation | Trinity | 1881 |
| Sears | Hoffman Estates | 1892 |
| Seattle Computer Products | Seattle | 1979 |
| Seattle's Best Coffee | Seattle | 1991 |
| SeaWorld | Orlando | 21 de março de 1964 |
| Seeburg Corporation | Chicago | 1902 |
| Sekai Project | Norwalk, Los Angeles | 2007 |
| Sequential Circuits | São José | 1970 |
| Shaba Games | São Francisco | 1997 |
| Sheaffer | Shelton | 1912 |
| Shelby SuperCars | West Richland | 1999 |
| Shen Yun | Deerpark | 2006 |
| Shield AI | San Diego | 28 de maio de 2015 |