| CoreCivic | Nashville | 1983 |
| CoreWeave | Roseland | 2017 |
| Corporation for Public Broadcasting | Washington, D.C. | 7 de novembro de 1967 |
| Coty | Nova Iorque | 1904 |
| CouchSurfing | São Francisco | 2 de abril de 2003 |
| Cox Communications | Phoenix | 1962 |
| Crackle | Culver City | julho 2007 |
| Cricket Wireless | San Diego | 1999 |
| Crosley | Cincinnati | 1937 |
| CrossFit | Santa Cruz | 2000 |
| CrowdStrike | Austin | 29 de agosto de 2011 |
| Crunchbase | São Francisco | julho 2007 |
| Culligan | Rosemont | 1936 |
| Cummins | Columbus | 1919 |
| Cushman & Wakefield | Nova Iorque | 1917 |
| CVS Health | Rhode Island, Woonsocket | 1963 |
| Cyan Worlds | Wilmington, Mead | 1987 |
| D23 | Burbank | 2009 |
| Dana Corporation | Toledo | 1904 |
| Databricks | São Francisco | 2013 |
| Datadog | Nova Iorque | 2010 |
| DataStax | Santa Clara | abril 2010 |
| DC Universe | Burbank | 2018 |
| Deckers Outdoor Corporation | Goleta | 1973 |
| Deere & Company | Moline | 1868 |
| Del Monte Foods | São Francisco | 1886 |
| Delta Air Lines | Atlanta | 17 de junho de 1929 |
| Diamond Multimedia | Los Angeles | 1982 |
| Dick's Sporting Goods | Coraopolis | 1948 |
| Dickies | Fort Worth | 1918 |
| Digi-Key | Thief River Falls | 1972 |
| Digital Eclipse | Califórnia | 7 de agosto de 1992 |
| Digital Photography Review | — | 1998 |
| DigitalOcean | Nova Iorque | agosto 2011 |
| Discovery Communications | Nova Iorque | 1982 |
| Disney Cruise Line | Celebration | 1995 |
| Disney Interactive Media Group | Glendale | 1994 |
| Disney Music Group | Burbank | 1998 |
| Disney-ABC Domestic Television | Burbank | 1983 |
| Dodge | Dodge Building | 14 de dezembro de 1900 |
| Dollar General | Goodlettsville | 1939 |
| Dominion Energy | Richmond | 1983 |
| Domino's Pizza | Domino's Farms, Ann Arbor Charter Township | 1960 |
| Dow Chemical | Midland | 1897 |
| Dr. Scholl's | Chicago, Londres | 1906 |
| Draken International | Lakeland | janeiro 2012 |
| Dremel | Racine | 1932 |
| Duke Energy | Charlotte | 1997 |