| Hennessey Performance Engineering | Houston | 1992 |
| Henry Ford Company | Detroit | 1901 |
| Hercules Inc. | Wilmington | 1912 |
| Heroku | São Francisco, Califórnia | 2007 |
| Hewlett-Packard | Palo Alto | 2 de julho de 1939 |
| HGST | São José | 2003 |
| Hiller Aircraft Company | Firebaugh | 1942 |
| Holiday Inn | Denham | 1952 |
| Holiday Inn Express | — | 1991 |
| Honeywell Aerospace | Phoenix | 1936 |
| Hormel | Austin | 1891 |
| HubSpot | Cambridge | 2006 |
| Hudson Motor Car Company | Detroit | 1909 |
| Hulu | Santa Mônica | março 2007 |
| Humana | Louisville | 1961 |
| Huntington Ingalls Industries | Newport News | 31 de março de 2011 |
| Hy-Vee | West Des Moines | 1930 |
| Hyperion Solutions | Santa Clara | 1981 |
| Hyperloop One | Los Angeles | junho 2014 |
| IBM Cloud Video | São Francisco | 2007 |
| Id Software | Richardson | 1 de fevereiro de 1991 |
| IGN | São Francisco | 29 de setembro de 1996 |
| Illumina | San Diego | 1998 |
| IMG | Nova Iorque | 1960 |
| In-Q-Tel | condado de Arlington | 1999 |
| Industrial Light & Magic | São Francisco, Letterman Digital Arts Center | maio 1975 |
| Inovio Pharmaceuticals | Plymouth Meeting | 1983 |
| Intel | Santa Clara | 18 de julho de 1968 |
| International Flavors & Fragrances | Nova Iorque | 1958 |
| International Harvester | Chicago | 1902 |
| Interpublic Group of Companies | Nova Iorque | 1961 |
| Intuitive Machines | Houston | 2013 |
| Intuitive Surgical | Sunnyvale | 1995 |
| Invesco | Atlanta | 1935 |
| Invicta Fighting Championships | Enka | 2012 |
| Invicta Watch Group | Hollywood | 1837 |
| Invitrogen | Carlsbad | 1987 |
| Iridium | McLean | 2001 |
| Iron Crown Enterprises | Virgínia | 1980 |
| IShares | São Francisco | 2000 |
| Ithaca Gun Company | Upper Sandusky | 1880 |
| ITT Corporation | Stamford | 1920 |
| J. C. Penney | Plano | 1902 |
| Jabil | São Petersburgo | 1966 |
| Jackson Guitars | Scottsdale | 1980 |
| JanSport | San Leandro | 1967 |
| Jasc Software | Eden Prairie | 1990 |
| JBL | Northridge | 1946 |